An original research article led by SCR scientists, titled “A microRNA signature and TGF-β1 response were identified as the key master regulators for spaceflight response” was published in the July 2018 issue of PLOS One. This landmark paper represents the scientific publication wholly derived from publicly available GeneLab data, illustrating the process of generating new hypotheses and informing future experimental research by repurposing multiple space-flown datasets. The research team, led by GeneLab scientists Drs. Afshin Beheshti (Wyle Labs/SCR), Shayoni Ray (USRA/SCR), Homer Fogle (Wyle Labs/SCR), Daniel Berrios (USRA/SCR), and Sylvain V. Costes (SCR), determined the potential of “master regulators” responsible for the increased health risks in spaceflight. The entire analysis was done using free & open GeneLab data from rodent research experiments previously flown on the Space Shuttle and ISS. Through an unbiased systems biology approach, the authors concluded that a circulating microRNA (miRNA) signature (comprised of 13 miRNAs) are driving the systems level response in the whole host which downregulates TGF-β1. These novel targets can be used as potential countermeasures to combat health issues that can occur in space. Research insights could shed light on the biological risks for astronauts associated with long-term space missions.
Download the full article here: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199621