Three GeneLab Analysis Working Group members participated in the 2019 LabRoots webinar series, Microbiology & Immunology. In a three-part presentation, Jon Galazka from Ames Research Center, Pen Jiang from Northwestern University, and Daniela Bedan at Weill Cornell Medicine, discuss GeneLab and discoveries made regarding the microbiota of spacecrafts and space-flown animals. This video was recently made available by LabRoots, producer of science news and educational webinars.
Part 1: GeneLab: Open Science for Life in Space, Jon Galazka, GeneLab Project Scientist, NASA Ames Research Center
To accelerate the pace of discovery from precious spaceflight biological experiments, NASA created the GeneLab data system (genelab.nasa.gov), which allows unfettered access to omics data from spaceflight and spaceflight-relevant experiments. GeneLab houses metagenomic datasets from spacecraft and relevant spacecraft models. Users can download these data and associated metadata to make new discoveries about how microbial communities may change and adapt to spaceflight.
Part 2: Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight, Peng Jiang, Research Assistant Professor, Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University
The gastrointestinal microbiota interacts with multiple aspects of mammalian physiological functions. Microbiome changes in response to the challenging space environmental factors, such as microgravity and radiation, are thought to be important for astronaut health during long-term missions. Spaceflight-associated changes in the gut microbiome include an elevated microbial diversity and an altered community structure, which appeared to be consistent across studies in both humans and mice. Ongoing studies are aiming to understand microbiome-host interactions during spaceflight and the significance of such interactions on mammalian functions such as metabolism, immune functions and sleep.
Part 3: Novel technologies to identify antimicrobial resistances in hospitals, urban environments and on the International Space Station, Daniela Bezdan, Research Director, Mason Laboratory of Integrative Genomics, Weill Cornell Medicine, Co-Chair NASA GeneLab Microbiome, Executive Director MetaSUB
With the revolution of next-generation sequencing technologies the field of microbiome and metagenomics research continues to expand and transform several fields. The Extreme Microbiome Project launched in 2014 characterizes the microbial communities of extreme sites on Earth. In 2015 we launched the International MetaSUB consortium with more than 200 members in 25 countries. We experimented with new technologies to find better solutions for the remote and rapid sequencing of infectious diseases in hospitals, on the International Space Station and in NASA clean rooms to inform the spacecraft assembly engineers and biological scientists of any potential bacterial or human contamination. Furthermore, we have been testing a broad range of cutting-edge technologies in the NASA Twins study. To better understand the impact of spaceflight on the human body and to prepare for future exploration-class missions, a pair of identical twin astronauts was monitored before, during, and after a one-year mission resulting in one of the most comprehensive studies ever have been made on one individuum.
