The space environment poses many challenges that can induce significant physiological changes to all species. One of those physiological changes is muscle atrophy, which can negatively impact the health of astronauts. A recent publication by Thomas Cahill, “Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight,” is based on the reanalysis of seven transcriptional profiling datasets (OSD-3, OSD-21, OSD-99, OSD-103, OSD-104, OSD-113, OSD-370) and details the effects of muscle responses to spaceflight. Thomas Cahill is from Queens University Belfast and contributes to the Multi-Omics and Animal GeneLab Analysis Working Groups (AWGs). GeneLab recently spoke to Thomas Cahill about this work and highlights how the GeneLab data systems and AWGs enabled this reanalysis.