A critical question in Space Biology is how will astronauts adapt to long-term spaceflight missions to Moon, Mars, and beyond? On November 25, twenty-nine scientific papers – including several from NASA’s GeneLab project – will offer answers to this question. These papers will be published in five Cell Press journals including Cell, Cell Reports, iScience, Cell Systems, and Patterns. They have been contributed by over 200 investigators from dozens of academic, government, aerospace, and industry groups, representing the largest set of astronaut data and space biology data ever produced, including longitudinal multi-omics profiling, single-cell immune and epitope mapping, novel radiation countermeasures, and detailed biochemical profiles of 59 astronauts who represent more than 10% of all humans who have ever been in space.
Some of the groundbreaking work reported in these papers utilized the GeneLab platform and its repository of spaceflight omics data, which are used to generate novel discoveries and develop new hypotheses for determining systemic biological responses occurring in spaceflight. Space biologists around the world are increasingly reliant on these omics data (epigenomics, transcriptomics, proteomics, metagenomics, and metabolomics) to maximize the knowledge gained from rare spaceflight experiments.
Below is a summary of three GeneLab-related papers authored by the GeneLab team and its Analysis Working Group (AWG) members, investigators. (Additional papers currently in review.)
- RNAseq analysis of rodent spaceflight experiments is confounded by sample collection techniques, Lai Polo, S., et al, iScience
- Multi-Omics Analysis Reveals Mitochondrial Stress as a Central Hub for Spaceflight Biological Impact, da Silveira, W., Cell
- Comparative Transcriptomics Identifies Altered Neuronal and Metabolic Function as Common Adaptations to Microgravity and Hypergravity in Caenorhabditis elegans, Willis et al., iScience
To view all 29 scientific papers published in the five Cell Press journals including Cell, Cell Reports, iScience, Cell Systems, and Patterns go to: https://www.cell.com/c/the-biology-of-spaceflight